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Endovascular Versus Surgical Treatment in Patients with Carotid Stenosis in the Carotid and Vertebral Artery Transluminal Angioplasty Study (CAVATAS): A Randomised Trial Lancet 357:1729-1737,1722, CAVATAS investigators, 2001 See this aricle in Pubmed Article Abstract The rates of major outcome events within 30 days of first treatment did not differ significantly between endovascular treatment and surgery (6.4% vs. 5.9%, respectively, for disabling stroke or death; 10.0% vs. 9.9% for any stroke lasting mo re than 7 days, or death). Cranial neuropathy was reported in 22 (8.7%) surgery patients, but not after endovascular treatment (p<0.0001). Major groin or neck haematoma occurred less often after endovascular treatment than after surgery (three [1.2%] vs 17 [6.7%], p<0.0015). At 1 year after treatment, severe (70-99%) ipsilateral carotid stenosis was more usual after endovascular treatment (25 [14%] vs seven [4%], p<0.001). However, no substantial difference in the rate of ipsilateral stroke was noted with survival analysis up to 3 years after randomization (adjusted hazard ratio=1.04 , 95% CI 0.63-1.70, p=0.9). Endovascular treatment had similar major risks and effectiveness at prevention of stroke during 3 years compared with carotid surgery, but wi th wide CIs. Endovascular treatment had the advantage of avoiding minor complications.

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